KMID : 0357920120460050503
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Korean Journal of Pathology 2012 Volume.46 No. 5 p.503 ~ p.506
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Castleman¡¯s Disease of the Renal Sinus Presenting as a Urothelial Malignancy: A Brief Case Report
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Jang Se-Min
Han Hu-Lin Jang Ki-Seok Jun Young-Jin Lee Tchun-Yong Paik Seung-Sam
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Abstract
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Castleman¡¯s disease is a rare benign lymphoproliferative disorder that frequently affects lymph nodes of the mediastinal thorax and the neck. It very rarely affects the renal sinus. We report a case of Castleman¡¯s disease arising in the renal sinus in a 64-year-old man. The patient visited the hospital with the chief complaint of hematuria. Abdominal computed tomography revealed a homogeneous mass in the sinus of the left kidney, radiologically interpreted as a malignant urothelial tumor. Subsequently, nephroureterectomy was performed, after which microscopic examination of the specimen revealed a diffuse lymphoproliferative lesion with reactive lymphoid follicles of various sizes and prominent plasma cell infiltration of interfollicular spaces, highlighted by immunohistochemical staining for CD138. The lesion was diagnosed as Castleman¡¯s disease of the plasma cell type. Although preoperative diagnosis of Castleman¡¯s disease is difficult and the incidence is exceedingly rare, it should be considered in the differential diagnosis of renal sinus tumors.
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KEYWORD
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Giant lymph node hyperplasia, Plasma cell type, Renal sinus, Urothelial malignancy, Kidney
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